The building was designed by Ludovico Maglietta in 1873 and has a double façade in Via Coltellini and Piazza Mazzini.
The temple has an elliptical plan with twelve columns topped by a cupola.
This is circled all the way around by the Women's gallery and a wrought iron gate surrounds the area housing the sacred texts and the cabinet containing the Torah scrolls.
The interior was decorated by Ferdinando Manzini.
The synagogue is located inside the area that comprised the city's ancient Jewish ghetto.