The Scuola Grande di S. Giovanni Evangelista is a confraternity building located in Venice (San Polo sestiere).
Founded in the 13th century by a group of flagellants it was later to become one of the 5 Scuole Grandi of Venice. These organisations provided a variety of charitable functions in the city as well as becoming patrons of the arts. The Scuola Grande di San Giovanni Evangelista is notable for housing a relic of the true cross and for the series of paintings it commissioned from a number of famous Venetian artists depicting Miracles of the Holy Cross. No longer in the school, these came into public ownership during the Napoleonic era and are now housed in the Gallerie dell'Accademia.