The relief is on the wall of the Scuola dei Varoteri (leather workers, tanners and fur vendors) facing Campo Santa Margarita. It shows the crowned Madonna with a mandorla on her chest. The relief used to be in the scuola's earlier location at the church of Santa Maria dei Crociferi, in Cannaregio, which no longer exists. The headquarters of the scuola moved to Campo Santa Margarita in 1725. The relief dates from 1501.