Commissioned from Bartolomeo Bianco in 1618 by Gio. Agostino Balbi, the palazzo marks the beginning of the monumental strada dei Balbi, starting from the piazza del Guastato and its garden layout, adjoining, to the east, the Francescan convent of the Santissima Annunziata.The orographic conditions of the site, which sits partially on a slope, and the palazzo’s links with the adjacent constructions of the church of San Francesco Saverio and San Girolamo and particularly the Jesuit College, another grandiose work by Bianco, represent a very fascinating urban-architectural ensemble characterised by a virtually inextricably complex spatial arrangement; in fact, there is a narrow junction.