A convent was established here in 1481 by a Benedictine nun called Marina Celsi, who had been abbess at San Matteo on Murano and of Sant'Eufamia on Mazzorbo. The first stone was laid in 1491, with work completed in 1498. Consecrated in 1583, it is said that Mauro Codussi may have had a hand in the design of the church, he having been working at the time on San Michele in Isola and San Zaccaria, also for Benedictines. Upon suppression by Napoleon in 1806 the nuns moved to San Zaccaria. The church was stripped and became a warehouse, a barracks, and in 1887 a hospice for cholera victims.