Sant'Angelo a Nilo is a Roman Catholic church located on the Decumano Inferiore (Spaccanapoli street) in Naples. It is known for containing the monumental tomb of Cardinal Rainaldo Brancacci (Italian: Sepolcro del Cardinale Brancacci) by Donatello and Michelozzo, one of the major sculptural works in the city.
The church is located in the core of the ancient Greek-Roman city: it takes its name from the Egyptian Nile, which was venerated here by the Egyptian merchants. It was begun in 1385 as a chapel, dedicated to Sts. Angel and Mark, by will of cardinal Rainaldo Brancacci, whose family had a palace nearby. The current appearance dates from a 1709 rebuilding, under the direction of Arcangelo Guglielmelli. Remains of the original Catalan-Gothic structure include the main portal, with an architrave featuring angels, and a fresco in the lunette with The Virgin Mary and Saints Michael and Baculus with Cardinal Brancaccio (15th century). A sculpture of St. Michael from another portal has been moved in the interior.
Artworks in the interior include the tomb of cardinal Brancaccio, canvasses from Luca Giordano school, a 16th-century altarpiece by the Sienese painter Marco Pino and a marble tabernacle in the sacristy.
Antonio Valente, the first major keyboard composer of the Neapolitan school, was organist here in 1565–80.