The Renaissance structure (1476-1482) houses the early-medieval shrine to Satyrus, brother of Saint Ambrose. The church is known for its false apse, an early example of trompe l'œil, attributed to Donato Bramante. The church lies on the site of a primitive worship place erected by the archbishop Anspertus in 879, dedicated to Saint Satyrus,confessor and brother of Saints Ambrose and Marcellina. The current church was instead built from 1472 to 1482 under commission from Duke Galeazzo Maria Sforza. According to some sources, the designer was Donato Bramante, who had recently moved from the Marche.