The church of San Francesco is one of the most important artistic and religious monuments of Piediluco. The building is dedicated to the saint of Assisi, in memory of his passage in this village, located a few kilometers away from the sanctuary of Greccio (in the province of Rieti) founded by himself.
From an architectural point of view, it is a longitudinal-plan church located above an imposing stepped staircase along the main road of the village. Its origin dates back to the end of the thirteenth century. The façade, which coincides with the external wall of a side flank of the building, is built of limestone with three pointed windows in the upper part and a carved door (now walled) and some bas-reliefs with crests and depictions with fishing scenes. The interior of the church has a single nave and still preserves several 16th-century frescoes of the Umbrian school both on the side walls and in the apse.