The church was built together with the convent in the late 16th century, probably on a pre-existing oratory of mediaeval origin, following the demolition of a women's nunciature, the Monastero della Santissima Annunziata, so as to make room for the new Medicean city walls. The nuns of the order of Santa Chiara established themselves here between the end of the sixteenth and the beginning of the seventeenth centuries in the building next to the church and so it took on the name of the convent of the Clarisse. The 'Chiesa dei Bigi' is on the left of the old convent, easily distinguishable for its belfry that rises up from the central part of the saddle roof above the main face in brickwork.